الملخص الإنجليزي
Objectives: To demonstrate the possible effect of smoking on
serum uric acid.
Methods: Subjects enrolled in study were divided into two
groups; nonsmokers and smokers, each with 60 male volunteers
of the same social class and dietary habit without history of
alcohol consumption, diabetes mellitus, hyperuricemia and gout,
renal, joint, lung or heart diseases. Fasting blood and random
urine samples were obtained from both groups for measurement
of uric acid and creatinine. Calculation of both urine uric
acid/urine creatinine ratio and fraction excretion of uric acid
were done. The results were statistically evaluated by standard
statistical methods.
Results: No significant differences in the age, serum creatinine,
spot urine uric acid/urine creatinine ratio and fraction excretion
of uric acid between the two groups, serum uric acid was
significantly lower in smokers. In smokers there was significant
negative correlation of smoking status (average number of
cigarette smoked/day, duration of smoking and cumulative
amount of smoking) with serum uric acid.
Conclusion: After exclusion of other factors affecting uric
acid level, the significant low serum uric acid level in smokers
was attributed to reduce endogenous production as a result of
chronic exposure to cigarette smoke that is a significant source
of oxidative stress. As this reduction is proportionate with
smoking status and predisposes to cardiovascular disease, it is,
therefore, recommended for smokers to stop or reduce smoking
and introduce serum uric acid estimation as routine test since its
cheap and simple to reflect their antioxidant level.
