NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations.
المصدر
World Journal of Gastroenterology. V. 13, 19, P. 2697-2702
مؤلف
Al-Moundhri, Mansour S.
الناشر
Baishideng Publishing Group Co
الملخص الإنجليزي
Aim: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic significance of NAT2. Methods: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses. Results: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance. Conclusion: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic significance.
الوصف
World Journal of Gastroenterology
Volume 13, Issue 19, 21 May 2007, Pages 2697-2702
المعرف
DOI: 10.3748/wjg.v13.i19.2697
