الملخص الإنجليزي
Objectives: Coronary artery (CA) involvement is the most well known complication
of Kawasaki disease (KD). Previous studies have suggested that QT dispersion has a
predictive value in diagnosing cardiac ischemia, ventricular arrhythmia, and sudden
cardiac death. However, limited data exits regarding the application of QT dispersion
in KD. Therefore, we sought to determine whether there is a relationship between
QT dispersion and CA involvement in patients with KD. Methods: We performed
a cross-sectional study of all consecutive patients with KD who were followed-up at
the Pediatric Rheumatology Department (Pediatrics Center of Excellence affiliated to
Tehran University of Medical Sciences, Tehran, Iran) from September 2013 to November
2015. Patients who met the criteria for KD, based on the American Heart Association
guideline, were enrolled in the study. We collected data regarding patients' demographics,
clinical manifestations, laboratory, and echocardiographic findings. Results: A total of
70 KD patients were identified, including 43 males (61.4%) and 27 females (38.6%). The
median age of patients was 21.0 (11.0–48.0) months. We found statistically significant
differences between age, gender, and platelet count among patients with and without
CA involvement (p < 0.050). Median corrected QT dispersion in patients with CA
involvement calculated from 12 leads in the acute phase was significantly higher compared
to the non-CA involvement group (108.0 (89.5–138.5) ms vs. 63.0 (54.0–74.5) ms,
respectively (p < 0.001)). Conclusions: Prolonged QT dispersion (corrected or noncorrected) during the acute and convalescence phases in patients with KD is associated
with coronary involvement.
