الملخص الإنجليزي
X chromosome inactivation is the epitome of epigenetic regulation and long non-coding ribonucleic
acid function. The differentiation status of cells has been ascribed to X chromosome activity, with two active X
chromosomes generally only observed in undifferentiated or poorly differentiated cells. Recently, several studies
have indicated that the reactivation of an inactive X chromosome or X chromosome multiplication correlates with
the development of malignancy; however, this concept is still controversial. This review sought to shed light on
the role of the X chromosome in cancer development. In particular, there is a need for further exploration of the
expression patterns of X-linked genes in cancer cells, especially those in head and neck squamous cell carcinoma
(HNSCC), in order to identify different prognostic subpopulations with distinct clinical implications. This article
proposes a functional relationship between the loss of the Barr body and the disproportional expression of
X-linked genes in HNSCC development.
