الملخص الإنجليزي
There are several synthetic treatments used to cure diabetes. However these treatments have some undesirable effects. Thus, there was an increasing effort in searching for plants possessing anti-diabetic activity with fewer side effects. The present study was conducted to evaluate the anti-diabetic and antioxidants effects of two Omani edible wild plants: Pteropyrum scoparium (Sidaf) and Oxalis corniculata (Muhammad) or their mixture in streptozotocin (STZ)-induced diabetic rats. Sprague Dawely male rats (n=37) weighing (250-300 g) were divided into five groups; first group: control non-diabetic rats (n=9), second group: control diabetic rats (n=7), third group: diabetic rats treated with Pteropyrum scoparium (n=7), fourth group: diabetic rats treated with Oxalis corniculata (n=7) and fifth group: diabetic rats treated with a mixture of Pteropyrum scoparium and Oxalis corniculata (n=7). Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg body weight). Animals were given the plant treatment by oral gavage at 5 ml once a week for a period of 8 weeks. The results reported that the STZ-induced diabetic group exhibited significant (p<0.05) hyperglycemia accompanied with weight loss, increasing Superoxide dismutase (SOD) activity, glutathione (GSH) depletion and total antioxidants capacity impairment (TAC) when compared to control non-diabetic group. Treatment with Pteropyrum scoparium and Oxalis corniculata or their mixture showed no significant positive improvement (p>0.05) on the final body weight, fasting blood glucose, cellular antioxidants markers and histopathology of pancreas of diabetic rats. The study established that there was no synergistic effect of Pteropyrum scoparium and Oxalis corniculata on STZ-induced diabetes and oxidative stress. Further research is needed to investigate the dose and time-dependent attributes of Pteropyrum scoparium and/or Oxalis corniculata in diabetic rats and to identify the bioactive ingredients of the two plants. Consequently, much effort is required to explore more Omani wild plants for their health benefits and bertanda medical uses.
