English abstract
Objectives: This study aimed to describe correlations between glucose, insulin and adipokine levels and
the homeostasis model assessment (HOMA) index with regards to the presence/absence of fat mass and obesity associated (FTO) rs9939609 and peroxisome proliferator-activated receptor (PPAR)-y rs1801282 single nucleotide
polymorphisms (SNPs) as indicators of body mass index in adolescents. Methods: This cross-sectional study was
conducted between September and December 2016 in Toluca, Mexico. A total of 71 students between 14–18 years
old were included. Various anthropometric and laboratory measurements were collected, including lipid profile,
glucose, insulin and adipokine levels and HOMA index. The degree of association between variables was evaluated
with regards to the presence/absence of the SNPs. Results: Leptin levels were significantly higher among female
students (P = 0.001), although adiponectin levels did not differ significantly (P = 0.060). There were significant positive
correlations between insulin levels and HOMA index with FTO (r = 0.391; P = 0.007 and r = 0.413; P = 0.005, respectively)
and PPARγ (r = 0.529; P = 0.007 and r = 0.537; P = 0.007, respectively) SNPs. Leptin showed a significant positive correl ation in the presence of PPARγ (r = 0.483; P = 0.007) or in the absence of both SNPs (r = 0.627; P = 0.039). However,
adiponectin was significantly negatively correlated in the presence of FTO, either alone (r = −0.333; P = 0.024) or in
combination with PPARγ (r = −0.616; P = 0.043). Conclusion: The presence of FTO and/or PPARγ SNPs might be related
to a genetic predisposition to metabolic syndrome
