English abstract
The incidence of end-stage kidney disease (ESKD) has been increasing over the past
few years as a direct result of the growing percentages of individuals with metabolic
syndrome. From 2001 to 2015 there were 2805 individuals diagnosed with ESKD
in Oman with a growing number of patients undergoing renal transplant as the gold
standard management of renal replacement therapy. Mycophenolate mofetil (MMF)
is one of the most frequently used medications as a part of immunosuppressive
medications in renal transplant specifically and solid organ transplant generally. We
are reporting a case of MMF-induced colitis in a young female patient that underwent
a living-related kidney transplant. She presented with a three-month history of watery
non-bloody and afebrile diarrhea. Investigations confirmed the diagnosis of MMF induced colitis. Histopathological examination of colonic biopsies obtained during the
colonoscopy procedure showed mildly increased crypt apoptosis, mild architectural
disarray, and focal crypt attenuation; features consistent with MMF-induced colitis.
The patient was treated by stopping the causative agent and replacing it with another
immunosuppressive medication, which led to complete resolution of the symptoms on
follow-up appointments. In this case report, we highlighted the underlying mechanism,
pathogenesis, and clinical features of MMF-induced colitis.
