Source
Oman Medical Journal, v. 39, no. 1, e591 p. [1-6].
English abstract
The association between vitamin D receptor (VDR) polymorphisms and
metabolic syndrome (MS) remains debatable. The current study aimed to determine
the correlation of VDR gene polymorphisms with MS among Jordanian women.
Methods: This case-control study enrolled 100 women with MS and 100 age-matched
women as control at Al-Hikma Modern Hospital in Jordan between January 2019
and January 2020. The levels of glycated hemoglobin, fasting glucose, triglyceride,
total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein
cholesterol, and 25-hydroxy vitamin D (25(OH)D) were determined from serum
samples of all participants. DNA was extracted from whole blood samples, and VDR
gene polymorphisms Apa1, Taq1, Bsm1, and Fok1 were analyzed by polymerase
chain reaction and restriction fragment length polymorphism. Results: There was a
significant difference between MS patients and control in terms of body mass index
(34.3±3.1 vs. 28.1±2.5), glycated hemoglobin (5.9±1.1 vs. 4.6±1.2), fasting blood
glucose (6.4±1.6 vs. 5.2±1.4), and total cholesterol (6.5±1.2 vs. 5.3±1.8). The results
also demonstrated a statistical difference in the number of MS patients and control
with 25(OH)D deficiency (69.0 vs. 33.0), 25(OH)D insufficiency (25.0 vs. 42.0), and
25(OH)D sufficiency (6.0 vs. 25.0) (p < 0.001). MS was significantly associated with
VDR polymorphisms among Apa1 and Fok1 genes. The genotype distribution for CC
(47.0% vs. 53.0%; p = 0.002) and CA (37.0% vs. 45.0%; p = 0.001) genotypes among
Apa1 VDR polymorphism, as well as among TT genotype (38.0% vs. 20.0%; p = 0.025)
among Fok1 VDR gene polymorphism significantly differed between MS patients and
healthy individuals. However, no associations were detected among Taq1 and Bsm1
VDR genotypes. Conclusions: VDR gene polymorphism of Apa1 and Fok1 variants may
increase the risk of metabolic syndrome among Jordanian women.
