Immunohistochemical expression of Ki-67 and p53 and their prognostic role in ameloblastoma : a longitudinal study.
Source
Oman Medical Journal, v. 39, no. 2, e607 p. [1-10].
Publisher
Oman Medical Specialty Board.
Original title
Immunohistochemical expression of Ki-67 and p53 and their prognostic role in ameloblastoma : a longitudinal study.
English abstract
Objectives: Ameloblastoma, comprising approximately 11% of all odontogenic tumors,
is a locally aggressive tumor with a high recurrence rate. This study aimed to assess the
immunohistochemical expression of Ki-67 and p53 and their association with clinical
and pathological factors among patients with ameloblastoma. Methods: Retrospective
follow-up data of patients histologically confirmed with ameloblastoma at Makerere
College of Health Sciences in Kampala, Uganda from January 2012 to December 2018
were retrieved. Factors associated with Ki-67 and p53 immunohistochemical expression
were determined using one-way one-way analysis of variance. Chi-square and Fisher’s
exact statistical tests were used to assess factors associated with recurrence. A two-tailed
p < 0.05 was considered statistically significant. Results: A total of 40 patients confirmed
histologically with ameloblastoma were included in the analysis. The majority (62.5%)
of cases were of the conventional type of ameloblastoma. The expressions of Ki-67 and
p53 were 52.5% and 85.0%, respectively. Recurrence was found in 47.5% of patients and
it was associated with conventional histological type (p = 0.042), segmental resection
(p < 0.001), tumor size (p < 0.001), and high p53 expression (p = 0.041). Conclusions:
Almost half the cases in this study had recurrence. The immunohistochemical expression
of p53 was significantly higher than that of Ki-67.
