This study aims to track the forms of historical communication and stages of development of political ties between Oman and Persia from emergence of Islam to the end of 7th Century of Hegira, and to explore the political, economic, social and cultural effects of Omani-Persian ties during the period of the study. The researcher adopted in the study the historical, descriptive analytical and comparative methodology by collecting the information related to the topic from various resources and studies, and tried to review the original and Arabized Persian bibliography in particular, and to use other supporting bibliography such as monumental found items and monetized coins, and to analyze the various events generated by cultural ties and influences between Oman and Persia. The study is divided into: Introduction, background, three chapters and conclusion. Background handles geography of Oman and Persia location, and historical roots of ties between them before Islam. Chapter one traces the phases of development of political ties between Oman and Persia. It reviews entry of Islam to Oman and Persia and Islamic conquest of Persia as well as Omanis' contribution to conquests. Chapter two focused on demonstrating the trade ties between Oman and Persia, by highlighting the trading role of ports and means of commercial transaction. It also addressed maritime trade that linked the two regions, and vessel industry and types and market types. Chapter three revealed social and cultural influences of relations between Oman and Persia. Social influences included immigrations between Oman and Persia and traditions and customs. In the cultural side it handled practical life and urban effects. Conclusion included the key results that were found by the study, primarily: Existence of cultural communication that extends over history and was nurtured by strategic neighborhood of the outstanding location of Oman and Persia, which enhanced the mutual influence between both regions.