This study aims to identify the level of prevalence of the Big Five Factors of Personality among Sultan Qaboos University students in the Sultanate of Oman and the most common signs of internet addiction in them. It also aims to identify the extent of contribution of the Big Five Factors of Personality in the prediction of the signs of internet addiction among these students. It also examines the extent of variations in the averages of the Big Five Factors of Personality and the signs of internet addiction based on the variations of sex (male and female) and the major (science and humanities). The sample of the of the study is 400 students, selected based on convenience sampling. To achieve the aim of the study, the descriptive correlational approach and the comparative causation approach were used. Moreover, Ibraheem's (2019) Internet Addiction Measurement and Abd'Khaliq's (2020) Arabian List for the Big Five Factors of Personality Measurement (the brief version) were applied in this study. The study reveals that agreeableness is the most common trait among Sultan Qaboos University students, while neuroticism is the least common trait among them. It also shows that the most common sign of internet addiction is 'I spend longer time using the internet than I planned to.' The results also display the possibility of predicting internet addiction through the traits of neuroticism and conscientiousness by 13.2%, as neuroticism can positively predict internet addiction, while conscientiousness can negatively predict internet addiction. The results also show statistically significant differences between males and females, for the males, in internet addiction and in the factors of extraversion and agreeableness, whereas there is no statistically significant difference between males and females in the factors of neuroticism, openness, and conscientiousness. The results also reveal statistically significant differences between the students of the humanities and science majors, for the humanities major, in internet addiction and neuroticism, while there is no statistically significant difference between the students of humanities and science majors in extraversion, openness, agreeableness, and conscientiousness.