AS EVERY YEAR POPULATION SIZES INCREASE, new diseases are discovered and scientists make new drugs, there is a need for an up dated and concise clinical text book for medical practitioners. The Current Medical Diagnosis and Treatment (CMDT) authors did a very good job of this by writing a text book which can be updated annually, with a quick reference link to an online preview. It was first published in 1987 to 1999 by Appleton & Lange and from 2000 till 2009 copyrighted by McGraw-Hill Incorporated and has long history of presenting updated medical knowledge in every edition. This 48th edition has outstanding features which make the book easier to use. Overall this is a very handy annually updated text book which can be used as a reference at a budget price in comparison to other books. It also has useful online access. It would be very interesting and informative for pre-med students and a ready reference for busy primary care practitioners and physicians.