وثيقة
Determination of total phenol, in-vitro antioxidant and anti-inflammatory activity of seeds and fruits of Zizyphus spina-christi grown in Oman.
المعرف
DOI: 10.12980/APJTB.4.2014APJTB-2014-0273
المساهمون
Khan, Shah Alam., مؤلف
Ahmad, Aftab., مؤلف
الناشر
Asian Pacific Tropical Biomedicine Press.
ميلادي
2014-07
اللغة
الأنجليزية
الملخص الإنجليزي
Objective: To perform phytochemical screening and to evaluate the in-vitro antioxidant and anti-inflammatory activities of ethanolic extract of seeds and fruits of Zizyphus spina-christi (ZSC) growing in Oman. Methods: Alcoholic extract of the dry powdered seeds and fruits of ZSC was obtained by cold maceration method and was subjected to preliminary phytochemical screening. Total phenolic content were estimated by using Folin-Ciocalteu reagent and 1,1-diphenyl-2-picrylhydrazyl (DPPH) was used to determine in-vitro antioxidant activity of plant extracts. Anti-inflammatory activity was investigated by protein denaturation method. Results: Phytochemical analysis of both the extracts revealed the presence of major classes of phytochemicals such as tannins, alkaloids, flavonoids, cardiac glycosides etc. ZSC seeds were found to contain the highest total phenolics but ZSC fruits exhibited the maximum antioxidant activity. The anti-inflammatory activity of both parts of the plant extract was significant and comparable with the standard anti-inflammatory drug, diclofenac. Conclusions: Based on the results of this pilot study, it can be concluded that ZSC is a good source of natural antioxidants which can be used to prevent progression of many chronic diseases. Further detailed phytochemical studies are needed to identify the chemical compounds responsible for exhibiting potent anti-inflammatory activity.
المجموعة
ISSN
2221-1691
URL المصدر
zcustom_txt_2
Al-Hakmaniyah, Fatma, Khan, Shah Alam & Ahmad, Aftab (2014). Determination of total phenol, in-vitro antioxidant and anti-inflammatory activity of seeds and fruits of Zizyphus spina-christi grown in Oman. Asian Pacific Journal of Tropical Biomedicine, 4 (
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