The objective of this experimental and numerical analysis research was to study the response of reinforced concrete bored piles in layered soils with a soft clay layer under axial and lateral loads. The first part of the study consisted of analysis of the full-scale pile load tests. This is followed by development of a numerical model and was validated using the results of the full-scale pile load tests. The full-scale pile load tests location was at Duqm Integrated Power and Water Plant Project at Duqm City – Sultanate of Oman. The site for the full scale consists of 3.0 m of sand overlying 4.50 m of soft clay that extends to the bedrock. The groundwater table was about 1.4 m below the ground surface. The full-scale tests were performed independently on two identical piles, one pile was tested for axial loading and the other for lateral loading. The piles were reinforced concrete bored piles with a 600 mm diameter and 16.0 m length. The test load for the axially loaded pile axial was 2750 kN whereas it was 100 kN for the laterally loaded pile. Two types of numerical models were developed in this research, one was axisymmetric two-dimension model for the axially loaded pile. The second one was a threedimensional model for the laterally loaded pile and for the combined loading. The fullscale testes results showed the load-settlement curve for axially loaded pile, and the loadlateral deformation curve for the laterally loaded pile. The numerical model showed perfect agreement with the results of the axial load test results and good agreement with the results of the lateral load test. The results show that the thickness of the soft clay significantly increases the settlement of the axially loaded piles. On the other, the effect of the soft clay layer on the deformations of the laterally loaded piles depends on the location of the soft clay layer below the ground surface. The lateral deformations increase significantly with the thickness of the soft clay layer, if the layer is within less than 3.0 m or 4 to 5 times the diameter of the pile below the ground surface. However, the soft clay has no effect on the pile lateral deformation of the pile if the clay is below 3 m (5 D) under the ground surface. Moreover, choosing the wrong soil model could lead to wrong results even when using the same soil parameters. It was found that the use of Modified Mohr-Coulomb model for all layers was the most suitable model. Furthermore, the groundwater table location affects the lateral deformation, while it had minimal effect on the pile settlement. Additionally, combined loading leads to an increase of both the pile settlement and lateral deformation. Finally, Increasing the slenderness ratio will increase both the pile settlement and lateral deformation. The lateral load increased the pile settlement by 14% while the axial load increased the pile lateral deformation by 9%