In recent years, cryptocurrencies have attracted a lot of attention and adoption. Cryptocurrencies are digital or virtual currency that operates in a decentralized manner with inherent security and transparency features. They offer numerous benefits, such as they are mobile payment friendly and readily accessible, have anonymity, limit intermediaries, and implement transparency, which make cryptocurrencies an excellent choice for trading, investments, and financial transactions. Apart from the algorithmic and infrastructure security risks that cryptocurrencies face, there are many application-level issues, such as security, privacy, trust, lack of regulations, and market volatility, that have a direct impact on end-user acceptance and their engagement with cryptocurrencies. Furthermore, current literature indicates that there is a lack of studies that coherently and comprehensively identify and analyze users’ concerns in cryptocurrencies. In addition, the primary methodologies utilized in these studies, such as surveys, interviews, or questionnaires, have inherent limitations. They usually have probable imposition, narrow scope, and limited sample space and participant knowledge, which may lead to misinterpreted results. Hence, there is a need to effectively understand and recognize such factors. The objective of this research is to systematically identify, analyze, and evaluate aspects that are more concerning and have a direct impact on how cryptocurrencies are adopted and utilized. It will potentially provide a strong foundation for creating efficient crypto-based financial services, products, and regulations with high end-user confidence. In this study, we will employ a mixed methodology. Literature review and thematic modeling are used to identify critical factors from the current literature. Quantitative techniques such as Statistical Analysis, Topic Modeling, and Sentiment Analysis driven by Social Media Analytics are exercised to further validate the accuracy and completeness of critical factors. The top five factors this research addressed are trust, security, regulation, market dynamics and innovation, and privacy. However, this research also shows that the market dynamics and innovation, and regulation were either weakly addressed or not addressed at all in the current literature. This attempt adds considerable value to the industry, users, and the scientific community in building a reliable foundation to improve cryptocurrency-based products and services. The recognition of these factors will enhance their trustworthiness, increase the adoption and confidence of end-users, and will also be validated and potentially add new knowledge of key factors to the state of the current body of knowledge.