The aim associated with this article is to examine the impact of knowledge and human resource management on the economic growth of Arab countries. The knowledge management is one of the aspects of the world economy, which contributes significantly to the advancement of economic development in the world, knowing that the Arab countries are suffering from delays in this area, so the problem of research was the delay of the Arab countries from keeping up with the development in the field of knowledge management. The research sample is represented by the United Arab Emirates, Saudi Arabia, Oman, Qatar and Bahrain. STATA was used to check the hypotheses with the help of the Generalized Method of Movement (GMM), and Robust Standard Error approaches. The results show that knowledge management and human resource management have a significant role in achieving their economic goals. These results are helpful for the policymakers while formulating policies related to knowledge management that enhance the economy of the country.