This thesis reconnoitered the interaction of two different amine molecules, Buspirone Hydrochloride (BUS) and Propranolol Hydrochloride (PRP) with three different synthesized Cucurbit[n]urils (CB)s, Cucurbit[6]uril (CB[6]), n-hydroxylated Cucurbit[6]uril (CB[6]-(OH)n] and Cucuribit[7]uril (CB[7]). Three binary inclusion complexes were investigated in solution and solid-state, by lyophilization and formation of physical mixtures in most of the cases 1:1 complexes were obtained, for each amine. 1HNMR and electrospray ionization mass spectrometry (ESI-MS) were used to study the complexes prepared in aqueous media. The lyophilized solid complexes were characterized by Fourier transform-infrared spectroscopy (FT-IR), powder X-ray diffractometry (PXRD), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). ESI-MS, FT-IR and PXRD experimental results demonstrated in this work reveal that BUS and PRP molecules form stable inclusion complexes with the three hosts. The TGA and DSC confirmed the enhancement of the thermal stability of each drug and the production of a thermally stable solid complex. The 1HNMR has shown that the guests' protons faced shifting in ppm and broadening of peaks upon formation of inclusion complexes with selected CB[n]s. The diffusion coefficients (D), acquired from the diffusion-controlled NMR Spectroscopy (DOSY) measurements, for complexation of BUS and PRP molecules with CB[6], CB[6]-(OH)n, and CB[7], donated lower values in m2 /s for complexation with CB[6] in the case of PRP and with CB[6]-(OH)n in the case of BUS. The results presented in this thesis show that the selected drugs are assumed to form strong inclusion complexes with CB[6], CB[6]-(OH)n, and CB[7] through non covalent interactions such as van der Walls interactions, hydrogen bonding, and ion dipole interactions resulting in enhanced chemical stability of these pharmaceutical compounds. This study generates initial data for potential drug delivery systems for these two compounds by CB[n]s.