Hemophagocytic lymphohistiocytosis (HLH) can occur as primary idiopathic syndrome or secondary to neoplastic, infection or autoimmune processes. It is characterized by the proliferation of histiocytes with phagocytosis of formed elements of blood. Clinical manifestations include signs and symptoms of immune activation and pancytopenia. This report presents a child with infection associated with HLH trigged by Acinetobacter baumannii sepsis. Multidrug-resistant Acinetobacter, an emergent nosocomial pathogen but so far in the literature, it has not been reported to cause HLH. From the 1Department of Pediatric Medicine, Institute of Post Graduate Medical Education and Research, Kalkota, India 2Department of Pediatric Medicine, North Bengal Medical College and Hospital, Darjeeling, India.