The study aims to identify the relationship between the problems of married female Master's students and the social support and mental health in a sample of married female Master's students. The sample number was 105 students. The researcher used the problems of married female Masters students prepared by the researcher, and the social support Scale for Zimet, Dahlem, and Zimet & Farley (Zimet, Dahlem, Zimet & Farley 1988), translated by the researcher, and the Psychometric Scale of Ahmed Abdul Khaleq (2011). The results indicate that there was a low average level of problems of married female master's students with low degree of repetition, a high level of social support, and a very high level of mental health. There are multiple correlations between the different variables of study in general, and the study showed no significant differences between the problems of married female master's students and social support and mental health depending on the variables of the number of children, age, the funding point of the study, the student's qualifications of the husband and the number of years of marriage. However, there are differences in the scale of problems of married female master's students in the problems of study, vocational and social in favor of part-time, while social support in the dimensions of supporting the husband and support the husband's family is in favor of full-time. The study concluded that the problems of married female Master's students explains that 17% of the variance in mental health and that the measure of social support explains 28% of the variance in the problems of married female Master's students on a sample of Nizwa University students.