Objective:To describe the epidemiology of acute pancreatitis in a tertiary care center in Oman. Methods:A retrospective study evaluated all adults (>18 yrs) who presented withfirstattack of acute pancreatitis to SQUH from 1stof January 2006 to 31stof December 2012. Results:One hundred seventy-four patients were found. The mean age of the cohort was 44 ± 11 years. 54% (n=95) were male and 45% (n=79) were female.Majorityof the cases were mild (n=131) compared to moderate (n=29) and severe (n=14).Sixty sixpercent (n=116) of the cases were secondary to alcohol and biliary tract diseases. Alcoholic pancreatitis occurred in 53% of the males whereas biliary pancreatitis occurred in 51% of the females. Pancreatitis recurred in 40% (n=71) of the cases, especially in alcoholic pancreatitis. 56 patients (32%) had complications, especially in the severe cases. Conclusion:The data about acute pancreatitis in Oman was similar to the Western countries. Pancreatitis occurred in males more than females. Alcoholic pancreatitis was more common in males, whereas biliary pancreatitis was more common in females. Alcoholic pancreatitis re-occurred in nearly half of the cases. Severe cases were associated with more complications and recurrence.