An 18-year-old woman presented to the outpatient dermatology clinic of the Hospital Universitario San Cecilio, Granada, Spain, in 2017 for a scheduled three-month follow-up appointment after having been prescribed 30 mg/day of oral isotretinoin for the control of severe acne. At the follow-up appointment, she reported multiple ulcerated exophytic dome shaped lesions prone to haemorrhage in the intergluteal fold and pubic region. She had no significant past medical history and did not report ever having had hidradenitis in the affected location nor any past trauma following hair removal. The results of complementary tests, including a complete blood count, general biochemistry tests and urinalysis, were within normal limits. A histological examination of the largest lesion was compatible witha diagnosis of pyogenic granuloma (PG). Subsequently, the isotretinoin dose was reduced to 15 mg/day and a topical application of clobetasol propionate twice daily was administered. The patient reported the complete resolution of the lesions within three weeks.