Objective: The objective of this study was to assess the quality of life (QOL) in people with epilepsy and to evaluate various factors affecting their QOL. Methods: A total of 116 patients with epilepsy and a control group of 116 apparently healthy persons were included in this case-control study which was conducted at the neurology outpatient clinic of Basrah General Hospital, Iraq. An interview was performed with the use of a special questionnaire, which included data pertaining to socio-demographic characteristics, and clinical characteristics (for patients with epilepsy only). The QOL was assessed with the use of a Short Form (SF-36) health survey. Results: Epileptic patients showed lower overall QOL scores as compared to controls. In the univariate analysis, patients who were older, from rural areas, and with low education and income levels had low er overall QOL scores. Frequent seizures as well as increased duration of epilepsy were also significant factors associated with reduction in QOL scores. In the multivariate regression analysis, age, educational level, income and frequency of seizures were significant determinants of QOL. Conclusion: Certain socio-demographic factors as well as clinical factors were crucial in determining QOL in epilepsy patients. Recognition of these factors will lead health professionals to develop different strategies to improve the QOL of those patients.