This workshop report describes plans for scientific drilling in the Samail ophiolite in Oman in the context of past, current, and future research. Long-standing plans to study formation and evolution of the Samail crust and upper mantle, involving igneous and metamorphic processes at an oceanic spreading center, have been augmented by recent interest in ongoing, low temperature processes. These include alteration and weathering, and the associated sub-surface biosphere supported by chemical potential energy due to disequilibrium between mantle peridotite and water near the surface. This interest is motivated in part by the possibility of geological carbon capture and storage via engineered, accelerated mineral carbonation in Oman.