Recently, during a routine histopathological examination, an excisional biopsy of a squamous cell carcinoma, on the lateral border of the tongue of a 70-year-old male patient, was evaluated and revealed a remarkable feature. In a haematoxylin and eosin (H&E) stained slide, numerous well defined polygonal isomorphous tiny structures, the majority of them stained with eosin and a few unstained, filled a lumen-like structure formed by the folding of the thin stratified squamous epithelium.