The spectrum of tropical nephropathies includes Acute Renal Failure (ARF) or Acute Kidney Injury (AKI) due to infective agents that are endemic in the tropics which include Leptospira (LS) and Dengue Viruses (DV). The major histological feature is Acute Tubular Necrosis (ATN).1, 2 We report the case of a patient who presented ARF with coinfection with both agents. The clinical manifestations were consistent with both diseases. A renal treatment was supportive and the outcome was positive. We conclude that co-infection with these two tropical agents was possible. It may have been overlooked when the diagnosis of one agent was confirmed, especially that aware of the possibility of coinfection, as the management may be different. Spontaneous full recovery in these circumstances is still possible with supportive treatment.