This article sought to summarize the scientific papers that were presented at the Advanced General Medicine Conference The Royal College of Physicians (London), The Ministry of Health (Oman) and Sultan Qaboos University with the highlights of each of them. The topics discussed at the conference are: Cytokines and Medicine 1: From fever to phenome, Cytokines and Medicine 2: From phenome to genome and back again, Venomous and Poisonous Animals of the Arabian Peninsula, Malaria and Other Imported Tropical Diseases, Advances in the Treatment of Bone Diseases, Acute Medical Problems in Pregnancy, Renal Disease in Pregnancy, Hormone Replacement Therapy in 2014, Concepts in Obesity, Acute Rheumatological Emergencies, Antiphospholipid Syndrome, Evidence-led Improvement of Patient Outcome and Patient Experience, Redesigning Service Delivery in Stroke Care to Continuously Improve the Quality of Patient Care, The Diagnosis and Management of Cardiac Failure, Making Sense of Transient Loss of Consciousness, Metabolic Surgery in Diabetes: Cutting to the solution, Acute Kidney Injury, and Volume Responsiveness.