The study aims to identify the social problems, facing the families of children with cancer, by identifying the most important social problems (family problems, psychological, societal and economical), and trying to reveal the most important mechanisms used to reduce the severity of social problems, and to develop proposals to reduce its exacerbation. The study relied on the descriptive analytical approach ,where two tools were used to collect data: the in-depth interview of (n=43) attendant either mother or father of sick children , and the other tool is the open interview with the (n=2) social workers at the National Center for Oncology at the Royal Hospital. The data was analyzed qualitatively and quantitatively, the results represented the following: The families of children with cancer suffer from several family problems, most notably (disturbance in roles, disturbance in family relationships, disturbance in the family situation that resulted in problems related to the study of children and problems related to the behavior of children and problems related to family dispersion), as for psychological problems signified in (problems related to fear, anxiety, depression, and social isolation), and societal problems represented in (the presence of a problem of communication between the family and the treating team, the problem of the family breadwinner with the employer) And finally, the economic problems represented in (the impact of the economical level of the family, the effect of the level of family income, and the presence of costs related to travel and treatment). The study sheds light on the most important mechanisms used by social worker to reduce the severity of social problems facing families of children with cancer, including: providing counseling therapy sessions for the family, studying the family's social status, communicating with the employer of the breadwinner of family, communicating with Ministry of Social Affairs and charities in providing financial support for families.