Objective: To study and compare different crude extracts from the leaves of Adenium obesum for antimicrobial potency and to perform different group tests. Methods: After processed, the leaves samples were used for extraction with methanol solvent by Soxhlet extraction method. The methanol crude extract was prepared by evaporating the solvent. The obtained extract was defatted by water and fractioned into different solvents. All the fractionated crude extracts were evaporated and used for antimicrobial study by disc method against pathogenic bacterial strains (Gram-positive and Gram-negative). The antimicrobial results for all crude extracts obtained from the leaves of Adenium obesum were compared with a standard antibiotic amoxicillin. Results: The calculated diameter of inhibition zone for all polarities crude extracts were in the range of 0-13 mm. The results showed that all crude extracts have strong potential against different pathogenic bacterial strains. Conclusions: The isolated crude extracts by Soxhlet method could be used as herbal or pharmaceutical medicine for the treatment of infectious diseases.