The study examined the determinants of depression among university students in Nigeria. Additionally, descriptive research design of survey type was used in this study. The population for this study comprised of all Nigeria undergraduate students. The sample for the study was 1,050 undergraduates. The instrument used for this study was a self-constructed, structured close ended questionnaire. Findings revealed that age and income were significant determinants of depression among university students in Nigeria while family type is not. It was therefore recommended that the University management should strengthen mental health services through health education to enable early detection and management of depression among students.