Air quality is a very important environmental and public health issue. Industrialization, urbanization, and transportation are major sources for air pollutions in most cities around the world. Air pollution level in many developing countries is deteriorating due to the fast growing of population and industrialization causing the release of several pollutants into the air. However, to avoid air pollution problems in those countries. They can learn from the developed nations by establishing good control to the air emission to the environment, though high regulation and law to protect it. After MECA's Ministerial Decision 41 /2017 issued, Port and Freezone authority carried out an intensive work to evaluate the impact of industrial activities on the residential area. This model is the first in Oman and for several other authorities within the country, it was worthy to document Sohar port case as a guideline for air quality monitoring network. This study gave a clear problem on air quality management that needs to consider before establishing any monitoring stations. This study outlines the guidelines for carrying out for ambient air quality monitoring including the selection of monitoring stations, number, and distribution of monitoring stations and some other of the main components. The guidelines have been prepared based on experience gained over the years in ambient air quality monitoring and management. The report additionally describes quality assurance needs in case any air quality observation. In recent years, several hundred epidemiological studies have emerged showing adverse health effects associated with short-term and long-term exposure to air pollutants due to the high concentration of particulate matter (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO) and unburned hydrocarbons (UHC). Most of the results of this study from the running of air dispersion model shows the direct effect of the operational processes of the port far below the much allowable limit for carbon monoxide, sulfur dioxide and nitrogen dioxide where 4.1%, 19.32% and 15%, respectively, if we consider the maximum limit to be 100% The statistical indicators to validate the model performances as per US EPA show close result between the modeled and monitoring data. FB, NMSE, IOA, MG, and VG used for model output validation. IOA for all pollutants except CO was close to the perfect model with a range between (0.53 for PM10 and 0.69 for NO2), the same observed by using FB, MG and VG. The correlation between the modeled number and monitored data show similar trends over the study period with maximum deviation presentation for PM10, NO2 and SO2 are 25%, 60%, and 31%, respectively. The dispersion patterns of those pollutants were simulated by employing AERMOD View which is a complete and powerful air dispersion modeling package which seamlessly incorporates the following U.S. EPA air dispersion models into a single integrated interface with an integrated state of the art meteorological Mesoscale Model (MM5) from 2012 – 2017. The results of this simulation used to quantify the ground level concentrations of all pollutants around the Sohar Port and Freezone.