An 83-year-old woman, with a past medical history of hypertension, diabetes mellitus and ischemic cardiomyopathy, was referred to the dermatology clinic of Complejo Hospitalario de Jaen in Jaen, Spain, in October 2013. The patient presented with erythematous indurated tumoural lesions with severe hyperkeratosis and impetiginisation on the anterior aspect of her left leg, which had appeared eight months prior . Fever, night sweats, weight loss, itching or other constitutional symptoms were absent. Neither hepatosplenomegaly nor axillary or generalised lymphadenopathy were detected. A systemic examination of the patient did not reveal any further abnormalities. As the majority of the patients with this condition are elderly, the therapeutical management may be complicated due to comorbidities and the potentially frequent number of relapses. Spontaneous remission only occurs in rare cases. Rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) chemotherapy and chemotherapeutic compounds applied for relapsing systemic B-cell non-Hodgkin's lymphoma have previously proven to be effective therapies. However, the current first line of treatment for this variety of lymphoma involves anti-CD20 antibodies, such as rituximab. These therapies can be used even during the early stages of the condition in order to improve rates of survival.