The aim of this study was to examine the reliability of change of direction repeated sprint test (CDRS) in wheelchair basketball players and to determine its physical components. Descriptive approach was used. 14 wheelchair basketball players (age: 35+6.08 years, trunk length: 74.435.49 cm, weight: 64.21:15.54 kg) volunteered to participate in this study. All participants performed 6x20m with changes of direction (30s recovery in between) twice with at least 48 rest. CDRS performance indices were expressed as total time (TT), best time (BT) and fatigue index (FI). They also performed hand grip test, 20m straight sprint (5m acceleration and 15m maximal speed were recorded) and medicine ball throw (3kg). Results showed that the TT and BT were reliable (ICC = 0.988, CV = 2.6%; ICC = 0.97, CV = 2.68, respectively). Limits of agreement of TT and BT were 3.6s and 0.62s, respectively. In addition, significant correlations were observed between both TT and BT and 5m (0.550, 0.456, respectively), 15m (0.635, 0.599, respectively) and 20m (0.638, 0.614, respectively). However, no significant relationship was observed between both TT and BT and hand grip and the medicine ball throw tests. These results are very important for physical conditioning professionals and coaches to assess change of direction repeated sprint ability and to select the appropriate training programs to develop this ability. The results of the study also showed that there is no relationship between the indicators of repeated sprint with change of direction with each of hand grip and throwing the medicine ball. In conclusion, the repeated sprint with change of direction test was reliability, and that the 5-15-20 m sprint test is a physical component of the proposed test. The researcher recommended conducting further research to ascertain construct validity and using the test extensively to determine the standard contents of the test.