Carbon capture, utilization, and storage (CCUS) is considered as one of the important and essential technologies that needs to be addressed in order to reduce the different anthropogenic greenhouse gases (GHGs) emissions in the atmosphere especially carbon dioxide (CO2) that mainly comes from industry and fossil fuels. Over the last few decades, the GHGs emission have shown an increasing trend worldwide. This in turn affects the global temperature and threatens the lives of organisms. Therefore, CCUS is considered as an emerging technology that requires an in-depth investigation to ensure safe and large- scale sequestration of the anthropogenic CO2. Underground storage areas have been suggested by scientists and researchers for CO2 storage. Depleted gas reservoirs are one of the suggest options for atmospheric CO2 storage to mitigate the level of the anthropogenic CO2. However, inside these reservoirs, various trapping mechanisms take place and therefore require thorough investigation. This study aims to investigate the impact of different parameters like connate water saturation, permeability and wettability on physical trapping mechanisms in a carbonate gas reservoir. In addition, effect of Henry’s law constant and salinity on the chemical trapping mechanisms were studied as well. A 3D RFD tNavigator simulator was used to investigate the impact of the various parameters on the CO2 trapping mechanisms. The results showed that for the physical trapping mechanism, as the connate water saturation increases the amount of CO2 stored in the depleted gas reservoir increases with time. A decrease in the reservoir permeability, increases the amount of CO2 that can be trapped in the reservoir by the action of capillary forces. In addition, as the rock becomes more water-wet, more CO2 is retained in the reservoir. As for the chemical trapping mechanism, the solubility of CO2 in water increases when Henry’s law constant decreases while keeping other factors constant. More CO2 will be soluble in brine with time and hence higher amount of CO2 will be trapped. In addition, increasing brine salinity decreases the CO2 solubility in brine. The findings of this study provide an insight on the feasibility of CO2 storage in depleted gas reservoir. The results also indicate that tNavigator software is capable of modelling CO2 storage in such storage systems. The results obtained from simulation clearly indicate that, RFD tNavigator was able to successfully predict the behaviors and performance of injected CO2 for storage purposes of CO2 inside depleted gas reservoirs.