The Ebola virus outbreak created great challenges for healthcare systems in Africa and other countries where patients were treated. Much of the reporting about Ebola preparedness outside the epidemic area has focused on European or North American responses. this article to add a perspective on how these challenges were faced in a different health economy in the Middle East, where resources are not always as accessible and social attitudes about the quarantine and burial of infectious patients are heavily influenced by prevailing religious customs. This report summarizes the Omani experience in preparing to identify and manage patients with Ebola virus disease. It highlights the process of creating policies and procedures and details the challenges in the implementation and auditing of the response plan.