This is the first large-scale study on the seroprevalence of bluetongue disease in camels in the Sultanate of Oman. Bluetongue (BT) is an infectious, non-contagious, vector-borne viral disease that affects domestic and wild ruminants, including cattle, buffaloes, camels, sheep, goats, and deer. The causative agent of the BT is a member of the Orbivirus genus, and it belongs to the Reoviridae family. This study aimed to estimate the seroprevalence and potential risk factors of BTV in Omani camels in northern Oman. The study also aimed to estimate the molecular prevalence of BTV in Omani camels. A cross-sectional study was conducted in the northern regions of Oman and Sera samples from 439 camels and out of them 100 blood samples were collected from five governorates from October 2016 to March 2017. Competitive enzyme-linked immunosorbent assay (c-ELISA) was used for screening serum for BTV antibodies and real-time reverse transcription polymerase chain reaction (RT-qPCR) was used for detecting BTV genomic RNA in blood. Data of risk factors associated with BTV were collected using a structured questionnaire. Statistical analysis was performed using the chi-squared test and binary logistic regression. The overall seroprevalence of BTV was 56.04%. BTV seropositivity was significantly associated with location, age of camels, sex, participation in events, and outbreak history whereas, tick infestation in farms and abortion history were not significant. The highest seroprevalence was in A'Dhahirah 81.08% and the lowest was in Al Buraimi 40.63%. The finding revealed the BTV seroprevalence was higher in camels older than 10 years (80%) than camels younger than 4 years old (18.27%) and camels aged between 4 to 10 years old (65.36%). Further, it was found that BTV seropositivity was higher in female camels (59.33%) than male camels (32.08%). Notably, camels that were mixed with small and large ruminants had a seroprevalence of 67.21%, while camels that were kept alone had a seroprevalence of 40.86%. The seroprevalence of BTV in camels that had outbreak history was 36.54% and 54.26% in aborted camels. The overall molecular prevalence in the regions was 26%. The highest active infection revealed by RT-qPCR was in Ash Sharqiyah (22%), A'Dhahirah (21.05%), and Al Batinah (27.78%). There was a good agreement between c-ELISA and RT-qPCR (kappa value = 0.794). The results of the present study showed that the BTV in northern Oman is enzootic, widely distributed and it is believed BT is an asymptomatic or sub-clinical disease in camels. Further investigation is required to determine the BTV serotypes that are circulating in the Sultanate of Oman.