The purpose of this study it to find the factors that affect student retention in higher education institutions in Oman. This study uses three independent factors that may affect the mediator, and this will reflect direct to affect the dependent variable. The three independent factors are student academic support, student motivation and student self-esteem, while the mediator is student satisfaction, and the dependent variable is student retention. To reach the result of this study, researcher collect data through primary and secondary data. The primary data were collected from the survey results and the secondary data were collected from previous studies which were talking about the same subject and/or want to achieve the same or close goal of the study. This is exploratory, detective quantitative study which explore the result through collecting data from the targeted sample. Researcher used a quantitative survey which were distributed between higher education institutions in Oman, which later got number of 570 responses of students from different academic levels and degrees (diploma, bachelor, master, and PhD) in different Oman regions. The data were collected and analyzed by the Statical Package for the Social Sciences (SPSS). Through the descriptive analysis, single and multiple linear regression, and Pearson correlation coefficient. The result shows the significant of this study in the relation between student academic support, student motivation and student self-esteem which shows that there is appositive significant relation between the three variables and student satisfaction and reflected positive significant relation between student satisfaction with student retention in higher education institutions in Oman. Based on collected results, researcher recommend that all higher education institutions in Oman can determine student retention through number of factors which can affect their satisfaction, by offering them all what can satisfy their need like the factors researcher used in this study, academic support, motivation, self-esteem. Simply student satisfaction can retain student in his/her institution.