In this paper, energy and exergy analysis of typical gas turbines is performed using average hourly temperature and relative humidity for selected Gulf cities located in Saudi Arabia, Kuwait, United Arab Emirates, Oman, Bahrain and Qatar. A typical gas turbine unit of 42 MW is considered in this study. The electricity production, thermal efficiency, fuel consumption differences between the ISO conditions and actual conditions are determined for each city. The exergy efficiency and exergy destruction rates for the gas turbine unit and its components are also evaluated taking ISO conditions as reference conditions. The results indicate that the electricity production losses occur in all cities during the year, except in Dammam and Kuwait for the period between November and March. During a typical day, the variation of the power production can reach 4 MW. The rate of exergy destruction under the combined effect of temperature and humidity is significant in hot months reaching a maximum of 12 MW in July. The presented results show also that adding inlet cooling systems to the existing gas turbine units could be justified in hot periods. Other aspects, such as the economic and environmental ones, should also be investigated.