Higher education institutions (HEIs') have responsibilities and interactions with societies to fulfill their particular and unstable needs. HEIs perform several social and economic roles in academia and research in the current knowledge-based economy. This study investigated the impact of Employee behaviors (EB) and High-Performance Work Practices (HPWP) on Organizational Innovation (OI) in the Omani Higher Education Sector. The study examined the effect of High-Performance Work Practices as an independent variable in three dimensions (HPWPs): Ability-enhancing (AE), Motivation-enhancing (ME), and Opportunity-enhancing (OE), and employee behaviors (EB) in three dimensions: Voice behavior (VB), Knowledge-sharing Behavior (KSB), and Innovative Behavior (IB) as an independent variable to the dependent variable Organizational Innovation (OI). The study was analytical and descriptive. An electronic survey was distributed to a targeted population of academic and non-academic employees working at Institutions of Higher Education in both the private and governmental sectors. 254 responses were received and analyzed using SPSS to test for the hypothesized relationships. It was revealed that Employees' behaviors (VB, KSB, and IB) and high-performance work practices (AE, ME, and OE) affect organizational innovation (OI). The HPWP significantly impacted OI more than EB; therefore, the study asserted the necessity to focus on High-performance work practices (HPWP), which is reflected positively by encouraging the employees to generate new ideas and implement innovative strategies and practices. The appropriate HPWP at the HEIs encourages the employees to engage in an innovative manner reflected in organizational innovation. Keywords: High-Performance Work Practices (HPWP), Organizational innovation (OI), Voice Behavior (VB), Innovative behavior (IB), Knowledge-Sharing behavior (KSB).