Fire poses a significant and persistent threat to buildings, and events like the September 11 incident at the World Trade Center in 2001 have highlighted the need to comprehend the behavior of structures under exposure to fire. Elevated temperatures caused by fire induce additional thermal stresses and reduce material strength, contributing to the potential failure of structural elements. To address these critical concerns, this research aims to gain a comprehensive understanding of the behavior of reinforced concrete buildings when subjected to various fire scenarios, different element sections, and load ratio. A 2-story reinforced concrete building, that represents a typical residential unit in Oman having a footprint of 13.91×22.5 meters, serves as the subject for investigation. The study employs OpenSees for Fire, utilizing nonlinear static analysis, to model the buildings response to fire scenarios. To explore the effects of different fire locations on the structures behavior under elevated temperatures, three fire locations are distributed on each floor, yielding a total of 15 fire scenarios. On the ground floor and first floor, the fire locations are strategically placed in three bays of sizes 5.3×3.6 meters, 4.4×4.1 meters, and 3.6×3.2 meters. However, on the first floor, the second bay has a different dimension of 4.2×4.1 meters due to changes in the layout. The ISO834 standard fire curve is applied as the thermal load during the analysis. Additionally, the results are compared for both direct and indirect effect conditions to comprehensively assess the structural response. Moreover, to investigate the effects of weak and strong columns and beams the study first reduced the beam sections by 0.5d and kept the columns as it is to have weak beams, after that we increased the sections by 1.5d kept the columns as it is to have strong beams, and the same thing has been done for the columns while the beams kept their original sections. To see the effects of load first the study reduced the loads by 50% and after that the load was increased by 150%. The study findings indicate that an increase in temperature directly affects the internal forces and deformations experienced by the beams and columns. This includes moments at spans and supports, axial forces, and deflections. The location of the thermal loading significantly impacts the displacement and bending moments in both spans and supports and the axial forces in spans. Closer members to the thermal loading location exhibit higher internal forces. Additionally, the thermal expansion of columns contributes to an upward displacement at the midpoint of the beams. The study also shows that increasing the depth of the elements results in reduced displacement, movement, and axial force values. Conversely, reducing the depth increases the displacement, moment, and axial force values. Similarly, increasing the load of the elements increases the displacement, moment, and axial force values, while reducing the load reduces the displacement, moment, and axial force values. The results demonstrate that reinforced concrete structures display remarkable strength under fire loads. Importantly, when structural elements are positioned away from the fire, the effects of the fire become negligible. Understanding the structural behavior under varying fire scenarios, load magnitude, and different element sections is crucial to enhance fire safety measures and optimizing the structural design to withstand potential fire hazards.