New distributional data and an updated and annotated checklist are provided for 27 species of Middle East Sarcophagidae of subtribe Apodacrina Rohdendorf. Of these, 17 species are recorded for Israel, 10 for Egypt, 4 for Turkey, 3 for Iran, 2 for each of Cyprus, Jordan, Saudi Arabia and United Arab Emirates, and 1 for Oman. No data are available for Bahrain, Iraq, Kuwait, Lebanon, Qatar, Syria and Yemen. Ten new species are described, including 5 from Israel (Apodacra idiopatica sp. n., A. melanura sp. n., Xeromyia moderabilis sp. n., X. nahalica sp. n., Xerophilomyia nigritarsus sp. n.), 2 from Saudi Arabia (Xeromyia jeddaense sp. n., X. ponti sp. n.), 1 from Cyprus (Xerophilomyia famagustica sp. n.), 1 from Egypt (Apodacra firanensis sp. n.), and 1 from Oman (Xeromyia omanica sp. n.). Comprehensive regional keys for the identification of genera and regional species are presented.