In this paper, simulation and sensitivity studies for propane oxidative dehydrogenation to which were propylene in a circulating fluidized bed is undertaken using a previously developed model. Various experimental kinetics, obtained by several investigators for the reaction using different catalysts, are employed in this study. A comparison is made for the performance of certain catalysts when used in a circulating fluidized bed reactor. The effects of changing reaction temperature, solid circulation rate, feed composition, pressure, and gas superficial velocity on reactant conversion and product selectivity and yields are studied. It was found that the catalyst prepared by Ramos et al. is superior to the others with respect to yield.