English abstract
Directed metal-catalyzed C-H Bond functionalization is an attractive topic in synthetic
chemistry. This methodology can provide an efficient way for the construction of a new
C-C bond selectively with no pre-functionalized reagents or intermediates. Therefore, it
is environmentally benign, and it can minimize the cost of synthesis. In these projects new
and novel amides acting as monodentate and bidentate directing groups have been
successfully synthesized and characterized by 1H, and 13C NMR Spectroscopy, GC-MS
spectrometry, IR-Spectroscopy, and Elemental Analysis. Furthermore, those directing
groups were investigated in C-H bond functionalization with different transition metals
and electrophiles. Moreover, since Ru is a cheap and common metal used in metalcatalyzed C-H bond f functionalization., a study on the ligand effect on Ru-catalyzed CH bond arylation of amide of 8-aminoqunolin was conducted. The study shows the most
effective ligands are tri-aryl-mono-phosphine of 145o
cone angle tri-cyclohexylphosphine. ligand of di-phosphine, amines, and carboxylic acid did not deliver the C-H
functionalization product.
