First Cytogenetic Profile of Omani patients with de novo myelodysplastic syndromes : comparison with data from Asia, Africa, Europe and North and South America.
Author
Udayakumar, Achandira M.
Publisher
College of Medicine, Sultan Qaboos University.
English abstract
Clonal cytogenetic abnormalities have been reported among 30–80% of patients with myelodysplastic
syndromes (MDS); however, 20–70% of patients with MDS show a normal karyotype that may nevertheless
harbour a cryptic genetic alteration. Earlier reports have suggested that the distribution of specific chromosomal
aberrations varies among Western and Asian countries, with geographical and ethnic differences in the frequency
of specific chromosomal aberrations. This article compared the cytogenetic data of 36 adult Omani patients with
MDS to previously reported data from other populations. Differences were noted between the percentages of
clonal aberrations and the median age of Omani subjects at presentation in comparison to individuals of different
ethnicities and from various geographical locations. To the best of the authors' knowledge, this is the first report
to describe the cytogenetic data of patients with MDS from Oman.
Identifier
DOI: 10.18295/squmj.2017.17.03.005
