Objective: To compare the effects of losartan and enalapril on themarkers of metabolic syndrome. Methods: One hundred and twenty six newly diagnosedhypertensive patients having other markers of metabolicsyndrome participated in this study. The study was performed inthe department of pharmacology, college of medicine at Ibn-SinaTeaching Hospital in Mosul city, Iraq, during the period betweenDecember 2007 and June 2009. The patients were divided into 2main groups: 1) Losartan group: consisted of 60 patients, and 2)enalapril group: Consisted of 66 patients. Waist circumference,weight, Body mass index, blood pressure, serum glucoseconcentration, triglyceride and HDL-cholestrol were measuredbefore and after administration of therapy. The effects of therapywere assessed by statistically comparing the results before andafter the drug administration. Results: Comparison of waist circumference, blood pressure,FSG, triglycerides of the patients before drug administration(baseline data), with those of the controls showed a significantelevation, while HDL-cholesterol showed a significant reduction.A significant reduction of waist circumference, BP, FSG and asignificant elevation of HDL-cholesterol were also noted aftertherapy with both losartan and enalapril. Conclusion: Both losartan and enalapril produced a significantreduction of markers of metabolic syndrome and may be regardedas effective drugs for treatment of hypertension in patients withmarkers of metabolic syndrome.