The aim of this study was to investigate the effectiveness of a Livermore-based career guidance program in developing cultural intelligence among students of grade 11 in Muscat Governorate. The study sample included 96 students who acquired scores below the average in the pretest. Students were divided into two groups: Experimental group that consisted of 48 student and control group that contained 48 students. The experimental group underwent a career guidance program. Cultural intelligence scale was applied, which included 20 statements distributed in four dimensions: metacognition, cognitive, motivational, and behavioral. The program consisted of 12 sessions to develop cultural intelligence among students. The results showed that there were statistically significant differences between the mean score of the experimental and the control group, and the differences in favor of the experimental group on all dimensions of the cultural intelligence scale. The results illustrated that there were statistically significant differences between the mean score of the pre and posttest of the experimental group indicating the differences in favor of the posttest. Results also showed statistical significance between experimental group response and gender which was in favor of the female students.