Herein, different known metal organic frameworks (MOFs) were examined as sorbent materials for solid phase extraction (SPE) of clarithromycin (CLA) from aqueous solution. The MOFs that were used zinc (II)-MOF with terephthalic acid, trimesic acid and biphenyl-4,4- dicarboxylic acid, as well as Al-terephthalate MOF. The preliminary experiments showed than none of these MOFs can interact with CLA, except Zinc (II)-2-amino- terephthalate (IRMOF-3). The adsorption efficiency of CLA via IRMOF-3 was found to be 73.9%. Interestingly, when composing this MOF with graphene oxide (GO) the adsorption efficiency was enhanced further to 79.8%. The CLA was determined by high performance liquid chromatography (HPLC) with UV detection at 266 nm. The analyte was run on C18 column maintained at 25 ℃, eluted using an isocratic mobile phase comprised of (A, 40%) methanol and deionized water (60%: 40%) and mobile phase (B, 60%) which was an aqueous acetic acid (AA, 0.1%, v/v) at a flow rate of 0.1 mL.min-l . The calibration curve of CLA was linear (R 2=0.9963) over the concentration range of 0.01- 5 mg.L-1. The limit of detection (LOD) and limit of quantification (LOQ) were 0.57 and 1.7 μg.L-1respectively. However, the extraction recovery from IRMOF-3@GO was only 14% when elution solvent was 60% [MeOH (60%): H2O (40%)]:40% [H2O-pH6] and the pH of analyte was 7.