Extensive research has been carried out to design an efficient refrigeration system that consumes less energy. This study investigated the use of a hydrocarbon blend refrigerant (LPG) mixed with mineral oil-based multi-walled carbon nanotube (MWCNT) nanolubricant at different concentrations (0.2, 0.4, and 0.6 g/L) as a replacement for the conventional working fluid R134a and polyolester (POE) oil. The results showed that using 0.4 g/L of nanolubricant with LPG reduced the pressure ratio and compressor energy consumption by 54.3% and 25%, respectively, and improved the coefficient of performance (COP) by 25% compared to R134a/POE. The study concluded that the optimal nanolubricant concentration among all working fluids was 0.4 g/L.