Thyrotoxic periodic paralysis is a rare neuromuscular disorder related to a defect in muscle ion channels and manifest by episodes of painless muscle weakness. Periodic paralysis is classified as hypokalaemic when episodes occur in association with low potassium levels or as hyperkalaemic when episodes can be induced by elevated potassium. Thyrotoxic hypokalaemic periodic paralysis may present as a life threatening emergency and unfamiliarity with the syndrome could result in a fatal outcome. Compliance with therapeutic management plays an important part in the treatment of this condition. Although the incidence is higher in the Asian population, it has been reported in other ethnic groups. This case report is of an Omani male presented to Buraimi hospital with acute muscle weakness.