This study aimed to identify the relationship between job alienation and its relation to the professional psychological stress among the administrative and technical employees in Muscat Municipality. The study sample was consisted of (400 male and female employees) of the administrators and technicians working in different departments of Muscat Municipality. Job Alienation Scale (Kickert, Higgs and Kuipers, 2011) was used, and the Psychological Stress Scale was prepared by using the scales of (Rawas, 2003; Al-Badour, 2006 and Ameriya, 2014). In addition, the professional Stress Scale (Naama, Ali 2011) was used. The researcher investigated the validity and reliability of the scales by applying them on the Omani environment and their significance was high. The results showed that the level of job alienation among the study sample members was within the average, as the mean average was ranging from (2.74) to (3.08), and that the level of the professional and psychological stress was average except both axes of the economic dimension and the financial return were of great level. In addition, there was a direct positive relationship between job alienation and the professional psychological stresses. Thus, the more the level of job alienation increases, the more the level of professional psychological stresses increases. As for the job alienation levels, there were differences in the axis of work stress favoring females, the axis of intention to leave work favoring the technicians, and the axis of meaninglessness feeling in ages ranging from 20 to 30 years in addition to the total score of ages ranging from 31 to 40 years. The results also showed differences in the psychological levels favoring females concerning the health dimension, favoring the males concerning the economic dimension and favoring the technicians concerning the job dimension. As for the professional stress, the study revealed differences in the axes of the professional stress levels concerning the axis of work environment favoring females, most axes of the field favoring females and most axes of ages between 20 to 30 years.