The study aims to identify the role of information systems in public sector institutions in achieving the priorities of Oman Vision 2040 and future aspirations. To achieve the objectives of the study, the mixed method was used by developing a questionnaire consisting of 84 items distributed into two themes. The first theme includes 78 items distributed into ten domains to examine the current status of the information systems' role in achieving the priorities of Oman vision 2040. The second theme consisted of six items that discussed future aspirations. A semi-structured interview was used based on the 11 questions to be sued as an interview guide. The questionnaire was distributed to (1004) study sample members, from whom only (600) responded. These respondents represent (34) government institutions. Three interviews were conducted with three decision-makers in governmental institutions. The results show that the current status of the information systems' role in the achievement of Oman vision 2040 was in the average range, which means the respondents indicated an intermediate level of their understanding of the importance of the information system in achieving the priorities of Oman vision 2040. They also showed an average grade on different dimensions, such as the role of institutions in enhancing Oman's rank in the global competitiveness indicators, integration between governmental institutions, data, information management and the efforts to build national capabilities. The same level is indicated in the potential to enhance the role of information technology in achieving Oman vision 2040 and mechanisms that are used to strengthen the role of IT in achieving Oman vision 2040. The results show a high level of challenges facing the development of IT and its infrastructure. Furthermore, the respondents indicated a high level of future aspirations. The results of the current status theme also revealed that there were statistically significant differences at the level (α ≥ 0.05) due to the institution, job, experience, and qualifications variables. In contrast, it shows no statistical differences due to the gender variable. For the future aspiration theme, the results show statistically significant differences due to variables of gender, job, experience and qualification. The researcher concluded with recommendations in light of the study's results. Most notably: the need to enhance workers' awareness and knowledge of the themes and priorities of Oman Vision 2040, developing information systems based on the vision's indicators through strengthening the infrastructure, building national capacities, and working to increase integration between institutions, activating information systems to achieve this integration, managing data and information, and providing the enablers to acquire all these.